ADIPOSE TISSUE-DERIVED MESENCHYMAL STEM CELLS INDUCE EXPANSION OF INTERLEUKIN-10-PRODUCING REGULATORY B CELLS AND AMELIORATE AUTOIMMUNITY IN A MURINE MODEL OF SYSTEMIC LUPUS ERYTHEMATOSUS

Mesenchymal stem cells (MSCs) are multipotent cells characterized by immunomodulatory properties and are therefore considered a promising tool for the treatment of autoimmune diseases.One functional B-cell subset, regulatory B cells (Bregs), has recently been shown to restrain excessive inflammatory responses in autoimmune diseases.In the present s

Diabetic kidney disease (DKD), which is diagnosed on the basis of reduced glomerular filtration rate (GFR), increased albuminuria, or both, is the leading cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide.Future projections anticipate a significant increase in diabetes cases, with close to 700 million diabetes patie

Plants have so much to offer as far as the discovery of new bioactive molecules is concerned.Among the several classes of phytochemicals, xanthones offer Large Bookcase greater structural diversity and pharmacological value.They are variable but definitely antioxidant in nature.Thus they are attractive targets for natural product and medicinal chem

A high rate of polypharmacy is, in part, a consequence of the increasing proportion of multimorbidity in the ageing population worldwide.Our understanding of the potential harm of taking multiple medications in an older, multi-morbid population, who are likely to be on a polypharmacy regime, is limited.This is a narrative literature review that aim

The pleasure derived from helping others is referred to as compassion satisfaction (CS).When a psychologist feels a too heavy demand to be compassionate and effective in helping, however, this may result in compassion fatigue (CF).CF may take the form of burnout or secondary traumatic stress (STS).The present paper focuses on two factors that may p